Here's a status update in case anyone is interested:
Most of the tips were things I was already doing (0.2mm layer height, 3 layers, 220 temp). Changing the slope isn't an option on a dome, since all angles are represented at some point on the dome. I changed the overlap to 50% with little change.
What shook stuff up was the over-extruding tip. I looked around and found the best way to test for this is to print out a hollow cube with no top and measure the wall thickness. I set Simplify3D to 0.48 width and a 1.0 extrusion ratio, and found the wall thickness was a whopping 0.96mm! I reduced the extrusion ratio to around 0.5 (I fiddled with it until I got an actual 0.48mm wall thickness). With this thickness, I was still having troubles, especially with holes in the outer walls. I ended up keeping the 0.5 extrusion ratio, but upping the filament wall thickness to 0.8mm. This seems to work much better, and at least with my initial tests, the artifacts are gone. I think with a 0.2mm layer height, the Davinci is uncomfortable with very low extrusion rates. The extrusion path is still wide, but at least Simplify3D knows about it know and seems to compensate OK. I will retest at 0.1mm and see what happens.
Does anyone have a recommendation on what the best layer height to extrusion width ratio is? Is my current ratio (0.2mm height / 0.8mm width) unusual?