from a design aspect, orientation is everything.
most printers build up from the bottom (ie: bed platform) - so how a piece is oriented on that platform will have a lot of bearing on the success of the print.
think of a capitol letter "T" - you would not want to print this in it's normal upright orientation as the crossbar would not print well - even with supports, rather you would flip it upside down so the crossbar is on the platform, and the leg in the air. Far greater chance of success in printing.
in general, try to orient things to use the least amount of support structures as possible.
also, for a fused filament printer, very small (less than 1"), very detailed things are very difficult to print well. those types of things are better suited for resin type printers, so knowing what type of printer would have a bearing on what you can expect out of it.
SD4 #1 & #2 - Lawsy carriages, E3D v6, Rumba controller board, mirror bed plate, X motor fan, upgraded PSU & Mica bed heater
SD4 #3 - in the works ~ Folgertech FT-5, rev 1
Printit Industries Beta Tester - Horizon H1