It will be easier to start by inputting any known value available. Otherwise you'll be chasing your tail with a bunch of best guesses. In your picture you are over extruding, I was thinking you were under extruding based on one of your comments of reducing the multiplier till you had holes in the perimeters. It didn't help that I then confused the two photos you had posted. In that other persons picture there is some form of mechanical slop in the system.
In your picture you have general over extrusion. If when you decrease the multiplier to get nice perimeters and infill, you get spaces between the lines on a bottom layer. This is where you can decrease the extrusion width to close that gap without messing up your calibration. You can also change extrusion width of infill patterns to achieve nicer surfaces. This is especially important on 100% infill parts.
I can assume you have a .4 nozzle so this means your general extrusion width will be .48. I like to use a first layer extrusion width of .36. Then I set perimeters to .48. Infill widths can range based on what filament and the type of part I am printing but (.44-.52)
I am not certain what "line" you are referring to. But if it's the space between the outer perimeters, that's the "infill" section. Remember that a Slicer is working in multiples of .48 in the X,Y axis. If a particular area of a print is 2mm wide and you have selected 2 perimeters. The Slicer is going to create tool paths to fulfill the perimeters first. This will give 4 lines that add up to 1.92mm. The Slicer then has to make some assumptions about the remaining .08mm. If you have selected zero infill it's not a problem as it will just leave a gap between the two sets of perimeters. If you selected 100% infill it's going to struggle to fill that tiny gap without over extruding. This is where tweaking that infill extrusion width can come in handy.
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