There is no infill option with Preform, so if your model is solid (as most models are), it will be printed solid. The reason for hollowing out an object is primarily to save resin, reduce weight, and to reduce the contact surface during print.
Load up a (relatively) large object in Preform, and it will tell you how much resin it will take (Volume). Hollow out the object in MeshMixer, then reload it in Preform, and you'll find that more often than not, the volume dropped by half or more.
If the model is solid, you don't have to worry about trapped resin, but if it's hollow you should provide some drain holes. Trapped resin might never cure.
If you're thinking about doing 50% infill for strength purposes, I wouldn't bother. This stuff, once fully cured is solid, however it can shatter, it doesn't have the tensile strength of ABS.
Besides, how do you plan to create a 50% infill inside your model, without creating hundreds of closed pockets. You might as well print it solid, because every one of those pockets will trap a little resin, and unless you plan on designing drain holes in every one of them....
Speaking of hollowing out an object, The general consensus is that a wall thickness of 2mm is more than adequate for medium size models. Models with a large cross section should have thicker walls. The thinnest wall that is reliable is about 1.6-1.7mm. Thinner than that, and you could end up with holes.
So as you have already surmised, small objects should be printed solid. Put it this way, if the cross section is about 4mm, Meshmixer would be able to hollow it out anyway.
To print or, 3D print, that is the question...
SD3 printer w/too many mods, Printrbot Simple Maker Ed., FormLabs Form 1+
AnyCubic Photon, Shining 3D EinScan-S & Atlas 3D scanners...
...and too much time on my hands.