A couple of things worth noting...
You mentioned that you set your multiplier to achieve .42mm wall thickness. It looks like (from plastic scribbler site) that you have a .40 nozzle and there for should be looking for a wall thickness of .48. I am only mentioning this as it would lead me to believe (Since your prints are getting better) that perhaps reducing it is masking some other issues.
So... The first issue I see in those prints is backlash or perhaps some wobble in the extruder assembly. Wobble is usually rather simple to remedy. I am not familiar with your particular printer so I can't point you in a particular direction. Belts are easy enough to tighten so maybe that's part of the problem.
It also appears that you may not have random start points selected in your Slic3r profile.
Previously you had mentioned layer heights not being set to round numbers such as .3 You may want to look into some calibration of your Z-axis. Same as you did for E: just call for a certain amount of travel and measure then adjust in EEPROM.
Often times an odd layer height number is derived based on the number of steps from your motor and the particular thread pitch of the Z-axis as a stepper motor can not make a partial step it will round to the closest step. With short prints this will have little to no effect but with taller prints can create a layer separation issue every so many layers.
Does that make sense?
Printit Industries Model 8.10 fully enclosed CoreXY, Chamber heat
3-SD3's & a Workbench all fully enclosed, RH-Slic3r Win7pro, E3D V6, Volcano & Cyclops Hot End
SSR/500W AC Heated Glass Bed, Linear bearings on SS rods. Direct Drive Y-axis, BulldogXL
Thanks to all for your contributions